https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Adjuvant chemotherapy in elderly patients with pancreatic cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18744 Wed 11 Apr 2018 10:05:26 AEST ]]> The prognostic and predictive value of serum CA19.9 in pancreatic cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25817 90 U/ml did not benefit from adjuvant chemotherapy (P = 0.7194) compared with those with a CA19.9 of ≤90 U/ml (median 26.0 vs 16.7 months, P = 0.0108). Normalization of CA19.9 within 6 months of resection was also an independent favorable prognostic factor (median 29.9 vs 14.8 months, P = 0.0004) and normal perioperative CA19.9 levels identified a good prognostic group, which was associated with a 5-year survival of 42%. Conclusions: Perioperative serum CA19.9 measurements are informative in patients with detectable CA19.9 (defined by serum levels of >5 U/ml) and have potential clinical utility in predicting outcome and response to adjuvant chemotherapy. Future clinical trials should prioritize incorporation of CA19.9 measurement at key decision points to prospectively validate these findings and facilitate implementation.]]> Tue 24 Aug 2021 14:31:04 AEST ]]> The histone deacetylase SIRT2 stabilizes Myc oncoproteins https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20120 Sat 24 Mar 2018 07:51:46 AEDT ]]>